Considering food security has always been one of the major goals of rural and agricultural development programs in Iran. Therefore, the present paper investigates the feasibility of introducing a management information system deployment model to improve food security in the agricultural sector of Khuzestan province. The research method was survey and field design. The research population was wheat farmers in Khuzestan province as 8500. The sample size was 400 using Cochran's formula. The sampling method was clustering method. Data analysis was performed using structural equations modeling and AMOS software. The results showed that the establishment of management information system had a significant effect on improving food security in the agricultural sector of Khuzestan province. Economic, technical and hardware requirements had the highest impact on MIS deployment to improve food security, respectively.