The COVID-19 pandemic and the related quarantine restrictions in Russia have seriously affected the activities of the media, which found themselves in a crisis situation and required special attention from the state. This article examines the situation that developed at the height of the pandemic (in March-February 2020) in online business media on the territory of such an actively developing economic region as the Republic of Tatarstan. The authors analyzed how the general quarantine regime affected the development of the leading online business publications in the region - the economic activities of their editorial offices and daily content, which was formed taking into account the self-occupation regime established in the republic. The empirical base of the study includes publications both in regional business online media and in similar foreign media, which allowed the authors of the article to make a comparative characteristic. The article concludes that the pandemic has contributed to a significant expansion of online business media issues by covering topics of universal nature. The formation of the information agenda during the period of self-isolation took place on the basis of four semantic categories: pandemic, self-isolation, quarantine, and economic crisis. The corresponding semantic component was built on these categories.