Predicting the Behaviour of the Senescence-Accelerated Mouse (SAM) Strains (SAMPs and SAMR) Using Machine Learning Algorithm

Document Type : Research Paper

Author

Software Department, College of Information Technology, University of Babylon

Abstract

A primary aspect of human aging is progressive neurological dysfunction. Due to the fundamental variations in aging in mice and humans, it is difficult to obtain and research effective mouse models. There are two types of tissue phenotypes that are distinct; one is the tissue for retina and one for the hippocampus. Each form has three strains. A variational formulation for sparse approximations is introduced in this work, inferring both the kernel hyper-parameters and inducing inputs by maximising a lower bound of probability of true log marginal. In order to account for more complexity with the time series, a model is built on this series with a correlated human model performance. The molecular senescence of the hippocampus and retina, both with accelerated neurological senescence (SAMP10 and SAMP8) models were presented. The purpose of the study is to specify the relationship between these genes or pathways that would provide insight into the mechanism for this phenotype which will be superior to the current incomplete state-of-the-art approximations. Furthermore, the combined study of the essential features of inbred strains and profiling of gene expression can help determine which genes are essential for complex phenotypes. However, the identification, sequencing and gene expression of full-genome polymorphism of inbred mouse strains with intermediate.

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