Predicting drug-target interaction based on bilateral local models using a decision tree-based hybrid support vector machine


1 Faculty of Electrical and Computer Engineering, University of Science and Technology of Mazandaran, Behshahr, Iran

2 Department of Computer Engineering and IT, Payam Noor University, Tehran, Iran

3 Young Researchers and Elite Club Qazvin Branch Islamic Azad University, Qazvin, Iran

4 Department of Electrical and Computer Engineering, Mahdishahr Branch, Islamic Azad University, Mahdishahr, Iran


Identifying the interaction between the drug and the target proteins plays a very important role in the drug discovery process. Because prediction experiments of this process are time consuming, costly and tedious, Computational prediction can be a good way to reduce the search space to examine the interaction between drug and target instead of using costly experiments. In this paper, a new solution based on known drug-target interactions based on bilateral local models is introduced. In this method, a hybrid support vector machine based on the decision tree is used to decide and optimize the two-class classification. Using this machine to manage data related to this application has performed well. The proposed method on four criteria datasets including enzymes (Es), ion channels (IC), G protein coupled receptors (GPCRs) and nuclear receptors (NRs), based on AUC, AUPR, ROC and running time has been evaluated. The results show an improvement in the performance of the proposed method.


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Volume 12, Issue 2
November 2021
Pages 135-144
  • Receive Date: 10 June 2020
  • Revise Date: 04 December 2021
  • Accept Date: 20 January 2021