The learning process of blood coagulation practicum for circulatory system material in Biology Education students aims to determine the ability of generic science skills. Descriptive method used in this study with research subjects consisted of 58 6th semester students. Data were obtained using essay tests. Achievement of generic science skills in students is focused on five aspects of generic science skills with research results that show, direct observation 98.83% (very good), symbolic language 38.79% (very poor), modeling 90.95% (very good), logical inference 39.51 % (very little), logic framework 94.90% (very very), with an overall average yield (75.6%) in the medium category. this generic science ability is still needed intensive guidance to increase shn for prospective teacher students biology.