Despite some studies in the analysis of technological innovation systems and factoryless manufacturing, these two issues have been analyzed comprehensively and at the same timeless, while entrepreneurship and employment development are among the first functions of technological innovation systems in countries. The aim of this study is to provide an integrated model for technological innovation in factoryless manufacturing in Iran. In this research, an integrated approach based on Grounded theory and structural-interpretive modeling has been used. The statistical population includes experts and experts in the field of factoryless producing. Using the purposive sampling approach, a total of 11 people were selected as participants in the study to the extent of theoretical saturation. Data were collected through interviews under the guidance of generalities and in a semi-structured manner and based on the data theory process, during the three stages of open, axial and selective coding, 71 concepts, 19 sub-categories and 6 main categories were identified and categorized. Then the final variables were graded by interpretive structural modeling at 4 levels of the main phenomenon, infrastructure, implementation and outcome. The results show that technological innovation acts as the main and effective basis for determining successful strategies in the field of factoryless manufacturing, which will lead to the interaction of the socio-economic environment in Iran.