Analysis of cancerous tumor growth by the competitive model based on the evolutionary game theory

Document Type : Research Paper

Authors
Atefeh Deris
Mahdi Sohrabi-Haghighat
Department of Mathematics, Arak University, Arak 38156-8-8349, Iran
10.22075/ijnaa.2021.21031.2223
Abstract
The behavior and growth of cancerous tumor is an interesting research subject and it has been widely analyzed from theoretical and empirical aspects. Various models have been applied to determine the growth pattern of cancerous tumor. In one of the current models, which we refer to as the competitive model, the tumor growth rate is determined based on the competition between the healthy and cancer cells. In this model, the competition matrix between the healthy and cancer cells is a type of prisoner's dilemma game matrix, so the growth curve of tumor has a sigmoid or S shape. According to the effective application of this model in determining the tumor growth rate, some methods to get rid of the model restrictions are presented so that it can be used for tumor progression pattern. Finally, in order to evaluate the efficiency of the developed model, it has been implemented in some empirical examples.
Keywords
Cancerous tumor
Curve fitting
Evolutionary game theory
Fitness
Growth rate
Prisoner's dilemma game
International Journal of Nonlinear Analysis and Applications
Volume 14, Issue 1
January 2023
Pages 1903-1910

  • Receive Date 03 August 2020
  • Revise Date 03 December 2020
  • Accept Date 12 November 2021

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