Nowadays, great attention is paid to the development of social entrepreneurship as a social and philanthropic mission, and one of the ways to solve some problems and social damages. Entrepreneurship has had a positive and direct impact on many different activities of countries and can cause economic development and create job opportunities; on the other hand, it can improve the social and cultural condition of the society. The present study was conducted with the aim of designing a model to explain the social responsibilities of universities with the approach of social entrepreneurship in the universities of Khuzestan province. The present research method is developmental-exploratory. The statistical population of the research in the qualitative phase includes 30 university professors that are selected using purposeful sampling and the brainstorming method (interview with experts) and it continued until it reached theoretical saturation in the quantitative phase according to Cochran's formula, the number of a statistical sample is equal to 380 people, which was selected through stratified random sampling method. In this research, the Delphi method based on the phenomenon-based identification, causal conditions, contextual and intervening factors, strategies and consequences and the relationship between them has been used. Then, the conceptual model of the research was prepared, compiled and drawn using the interpretative structural modelling method. By entering the operational stage and using structured questionnaires whose categories were extracted from similar domestic and foreign research questionnaires and based on the opinion of subject matter experts, their validity and reliability have been proven using standard tests, the relationships between the identified components were investigated and finally, the operational model of the research was evaluated using Spss 24 and Smart Pls3 software. The results showed that 36 concepts regarding social entrepreneurship and 48 concepts of social responsibility were obtained. Also, by examining the relationships between the variables and evaluating the model, it was found that the obtained model also has an excellent fit.