Profitability is an intrinsic factor to keep the bank strong because profitability shows that a bank is operating efficiently. Considering the strong relationship between a strong banking system and economic growth, research on the determinants of bank profitability has been widely conducted. However, according to the extent of the studies, there is no proper and consistent attitude regarding the factors that determine the bank's profitability. Accordingly, the purpose of this research was meta-analysis of factors affecting the profitability of the banking industry. This research was based on the purpose of applied-developmental research. In order to achieve the purpose of the study, first, articles were searched with the keywords of banking profitability and banking performance, and finally, 51 studies were selected for meta-analysis based on the inclusion and exclusion indicators of the articles. In order to analyze the data in this research, the overall effect size index and Z value were used to check its significance. Also, in the diffusion detection section, along with the use of funnel and precision charts, Duvall and Toid indices have been used to show point estimates and obtain error-free Q and N values. The results of the research show that there are 14 effective factors for the profitability of the banking industry, the most important of which are inflation, deposits and operational efficiency.